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. 2025 Mar 12;26(1):20-25.
doi: 10.4274/jtgga.galenos.2024.2024-6-1.

The effects of non-functioning pituitary adenomas on pregnancy

Özge Baş Aksu  1 , Özgür Demir  1 , Asena Gökçay Canpolat  1 , Demet Çorapçıoğlu  1
Affiliations

The effects of non-functioning pituitary adenomas on pregnancy

Özge Baş Aksu et al. J Turk Ger Gynecol Assoc. .

Abstract

Objective: Non-functioning pituitary adenomas (NFPAs) are a group of hormonally inactive adenomas. The aim of this study was to investigate the possible effects of NFPAs on pregnancy.

Material and methods: Thirty patients with NFPAs and without hormone deficiency or excess were included. We retrospectively evaluated anterior pituitary hormone levels, follow-up periods, pituitary imaging findings, symptoms associated with adenoma size increase during pregnancy, adverse pregnancy outcomes, delivery procedures, pregnancy week at delivery, birth weight, and lactation duration.

Results: The mean age of the patients was 41.26±9.06 years, and the mean follow-up after diagnosis was 92.8 months. Seven were diagnosed with macroadenomas (defined as the largest diameter >10 mm) and 23 had microadenomas. There were 92 pregnancies in total. The incidence of nausea-vomiting and visual impairment during pregnancy were more common in the macroadenoma group (p=0.016 and p=0.042, respectively). Spontaneous pregnancy rates were high. The patients with NFPAs did not have an increased risk of pregnancy-related complications compared to the general population, and there were no obvious negative effects on fetal development or lactation. NFPAs were not associated with an increased cesarean section rate.

Conclusion: These findings suggest that NFPAs, even macroadenomatous NFPAs, have no negative effects on pregnancy outcomes, fetal development, or lactation.

Keywords: Pituitary; adenoma; non-functioning pituitary adenomas; pregnancy.

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Conflict of interest statement

Conflict of Interest: No conflict of interest is declared by the authors.

References

    1. Chanson P, Wolf P. Clinically non-functioning pituitary adenomas. La Presse Médicale. 2021;50(4):104086. doi: 10.1016/j.lpm.2021.104086. - DOI - PubMed
    1. Ntali G, Wass JA. Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas. Pituitary. 2018;21(2):111–8. doi: 10.1007/s11102-018-0869-3. - DOI - PubMed
    1. Benson JC, Malyuk DF, Madhavan A, Guerin JB, Krecke KN, Little JT, et al. Pituitary volume changes in pregnancy and the post-partum period. Neuroradiol J. 2024;37:39–42. - PMC - PubMed
    1. Lambert K, Rees K, Seed PT, Dhanjal MK, Knight M, McCance DR, et al. Macroprolactinomas and nonfunctioning pituitary adenomas and pregnancy outcomes. Obstet Gynecol. 2017;129:185–94. - PubMed
    1. Karaca Z, Yarman S, Ozbas I, Kadioglu P, Akturk M, Kilicli F, et al. How does pregnancy affect the patients with pituitary adenomas: a study on 113 pregnancies from Turkey. J Endocrinol Invest. 2018;41:129–41. - PubMed

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