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. 2025 Jul 1;110(7):1660-1664.
doi: 10.3324/haematol.2024.286972. Epub 2025 Mar 13.

Plasma exchange for hyperammonemia-induced reduced consciousness after PEG-asparaginase in an adult patient with acute lymphoblastic leukemia

Felix Klingler  1 , Anika Forstreuter  1 , Luisa Stegat  1 , Sofie Kämereit  2 , Felix Ullrich  1 , Florian Udonta  1 , Christian Krebs  3 , Dominik Wichmann  4 , Carsten Bokemeyer  1 , Nicola Goekbuget  5 , Walter Fiedler  1 , Franziska Modemann  6
Affiliations

Plasma exchange for hyperammonemia-induced reduced consciousness after PEG-asparaginase in an adult patient with acute lymphoblastic leukemia

Felix Klingler et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Treatment history of a 19-year-old patient with hyperammonemia-induced reduced consciousness. Laboratory test results are presented as n-fold of upper laboratory normal (ULN) or lower laboratory normal (LLN) as appropriate. Leukemic meningitis was ruled out by cytomorphology and fluorescence-activated cell sorting (FACS). Infectious diseases of the central nervous system (CNS) were ruled out by polymerase chain reaction (PCR) and serology (cytomegalovirus [CMV], varicella zoster virus [VZV], herpes simplex virus [HSV]) or by serology only (Toxoplasma) or by PCR only (human herpes virus 6 [HHV6] and 8 [HHV8]), Asn.: asparaginase; AST: aspartate aminotransferase; BL: bronchial system; CHE: cholinesterase; CT: computed tomography; ICU: intensive care unit; i.th.: intrathecal; LP: lumbar puncture; MRI: magnet resonance imaging; PE: plasma exchange; PEG-asn.: PEG-asparaginase; Sono: sonography; SVT: sinus venous thrombosis.
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References

    1. Alaggio R, Amador C, Anagnostopoulos I, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 2022;36(7):1720-1748. - PMC - PubMed
    1. Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022;140(11):1200-1228. - PMC - PubMed
    1. Goekbuget N, Stelljes M, Viardot A, et al. First results of the risk-adapted, MRD-stratified GMALL trial 08/2013 in 705 adults with newly diagnosed acute lymphoblastic leukemia/lymphoma (ALL/LBL). Blood. 2021;138(Suppl 1):362.
    1. Asselin B, Rizzari C. Asparaginase pharmacokinetics and implications of therapeutic drug monitoring. Leuk Lymphoma. 2015;56(8):2273-2280. - PMC - PubMed
    1. Sudour H, Schmitt C, Contet A, Chastagner P, Feillet F. Acute metabolic encephalopathy in two patients treated with asparaginase and ondasetron. Am J Hematol. 2011;86(3):323-325. - PubMed

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