Tunneling through cardiac jelly

José Luis de la Pompa^{1

2}

Affiliations

¹ Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
² Ciber de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain.

Comment

José Luis de la Pompa. Science. 2025.

. 2025 Mar 14;387(6739):1151-1152.

doi: 10.1126/science.adw1567. Epub 2025 Mar 13.

José Luis de la Pompa^{1

2}

¹ Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
² Ciber de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain.

Abstract

Membrane projections from muscle cells enable signaling in the developing mouse heart.

Tunneling nanotube-like structures regulate distant cellular interactions during heart formation.
Miao L, Lu Y, Nusrat A, Fan G, Zhang S, Zhao L, Wu CL, Guo H, Huyen TLN, Zheng Y, Fan ZC, Shou W, Schwartz RJ, Liu Y, Kumar A, Sui H, Serysheva II, Burns AR, Wan LQ, Zhou B, Evans SM, Wu M. Miao L, et al. Science. 2025 Mar 14;387(6739):eadd3417. doi: 10.1126/science.add3417. Epub 2025 Mar 14. Science. 2025. PMID: 40080583