Exercise Training and Rehabilitation in Cardiac Amyloidosis (ERICA) Study: Rationale and Design

Abstract

Notwithstanding the dramatic improvement associated with Tafamidis in Heart Failure due to wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), the effect of exercise training on ATTRwt-CA remains unexplored. We hereby present rationale and design of the Exercise training and Rehabilitation in Cardiac Amyloidosis study. This interventional, controlled study will randomize ATTRwt-CA patients into a control group and a training group. Primary endpoint will be the distance obtained at the 6-min walk test. Quality-of-life, peak oxygen consumption, left and right heart architecture and function, and natriuretic peptides will be secondary endpoints.

Keywords: Cardiac amyloidosis; Cardiomyopathies; Exercise training; Heart failure; Rehabilitation; Wild-type transthyretin.