The APPLE's core question-upfront osimertinib versus the sequential approach for EGFR mutated non-small cell lung cancer
- PMID: 40083489
- PMCID: PMC11898351
- DOI: 10.21037/jtd-24-1785
The APPLE's core question-upfront osimertinib versus the sequential approach for EGFR mutated non-small cell lung cancer
Keywords: Lung cancer; brain metastasis; circulating tumour DNA (ctDNA); tyrosine kinase inhibitor (TKI).
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-24-1785/coif). A.C.T. reports consulting for Amgen, Bayer, Pfizer; research funding from AstraZeneca (to Institution), Takeda (to Institution); and honoraria from Amgen, AstraZeneca, Daiichi Sankyo, Guardant, Janssen, Juniper Biologics, Pfizer, Roche, Takeda; all outside the submitted work. The other authors have no conflicts of interest to declare.
Comment on
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Overall Survival From the EORTC LCG-1613 APPLE Trial of Osimertinib Versus Gefitinib Followed by Osimertinib in Advanced EGFR-Mutant Non-Small-Cell Lung Cancer.J Clin Oncol. 2024 Apr 20;42(12):1350-1356. doi: 10.1200/JCO.23.01521. Epub 2024 Feb 7. J Clin Oncol. 2024. PMID: 38324744
References
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- Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-46. 10.1016/S1470-2045(11)70393-X - DOI - PubMed
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