Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jan 27;14(4):185-193.
doi: 10.1055/s-0045-1801865. eCollection 2024 Oct.

Seroprevalence and Associated Outcomes of Parvovirus B19 Infection in Human Immunodeficiency Virus Patients: A Systematic Review

Sagad O O Mohamed  1 , Reem A A Mohamedelmugadam  2 , Safa A M Almardi  3 , Tassnem H M Ahmed  3 , Malaz E H Ibrahim  3 , Abdalla O O Mohamedali  4
Affiliations
Review

Seroprevalence and Associated Outcomes of Parvovirus B19 Infection in Human Immunodeficiency Virus Patients: A Systematic Review

Sagad O O Mohamed et al. Avicenna J Med. .

Abstract

Several case reports have highlighted the presence of serious clinical outcomes in patients with human immunodeficiency virus (HIV) related to parvovirus B19 (PVB19). However, epidemiological studies have produced inconsistent and varying results regarding the prevalence of PVB19 and its associated clinical outcomes in this population. These inconsistencies highlight the need for a thorough summary and analysis of present data to better understand burden and impact of PVB19 on HIV patients. This review aims to provide an overview of current evidence and identify areas for further research. Following the Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines, a comprehensive search was conducted across Medline/PubMed, Google Scholar, and World Health Organization Virtual Health Library Regional Portal. The pooled prevalence with the corresponding 95% confidence interval (CI) was measured using Comprehensive Meta-Analysis Software version 3.3. Publication bias was estimated based on Begg's test, Egger's test, and examination of the funnel plots. A total of 16 studies, with 2,122 HIV patients, were included in the meta-analysis. The pooled prevalence of detecting anti-PVB19 immunoglobulin G, anti-PVB19 immunoglobulin M, and PVB19 DNA particles among HIV patients was 43.6% (95% CI: 23.5-66.1%), 5.10% (95% CI: 2.10-12.10%), and 6.40% (95% CI: 4.10-9.90%), respectively. In the overall population of HIV patients, most of the included studies did not establish a statistically significant association between PVB19 infection and the occurrence of anemia. PVB19 infection is commonly detected in individuals with HIV. However, anemia due to PVB19 is not common in this population. Findings from a few studies suggest that PVB19 infection may contribute to anemia in individuals with advanced HIV disease or significant immunosuppression. Additional research is needed to confirm and clarify these relationships in individuals with HIV, particularly those with compromised immune systems.

Keywords: HIV; PVB19; anemia; human immunodeficiency virus; parvovirus B19.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
Flow chart for studies' selection process.
Fig. 2
Fig. 2
Seroprevalence of PVB19 IgG antibodies in patients with HIV. HIV, human immunodeficiency virus; IgG, immunoglobulin G; PVB19, parvovirus B19.
Fig. 3
Fig. 3
Seroprevalence of PVB19 IgM antibodies in patients with HIV. HIV, human immunodeficiency virus; IgM, immunoglobulin M; PVB19, parvovirus B19.
Fig. 4
Fig. 4
Prevalence of PVB19 DNA particle detection in patients with HIV. HIV, human immunodeficiency virus; PVB19, parvovirus B19.
Fig. 5
Fig. 5
Funnel plot showing evidence of publication bias among studies in the meta-analysis of seroprevalence of PVB19 DNA particles, IgM antibodies, and IgG antibodies in patients with HIV. HIV, human immunodeficiency virus; IgG, immunoglobulin G; IgM, immunoglobulin M; PVB19, parvovirus B19.
See this image and copyright information in PMC

References

    1. Le Hingrat Q, Sereti I, Landay A L, Pandrea I, Apetrei C. The Hitchhiker Guide to CD4 + T-cell depletion in lentiviral infection. a critical review of the dynamics of the CD4 + T cells in SIV and HIV infection . Front Immunol. 2021;12:695674. - PMC - PubMed
    1. German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’ . Human Immunodeficiency Virus (HIV) Transfus Med Hemother. 2016;43(03):203–222. - PMC - PubMed
    1. Nasir I A, Medugu T, Dangana A. Human parvovirus B19-associated hematopathy in HIV disease: need for clinicopathological revisit. J Biomed Res. 2018;32(01):1–2. - PMC - PubMed
    1. Abkowitz J L, Brown K E, Wood R W, Kovach N L, Green S W, Young N S. Clinical relevance of parvovirus B19 as a cause of anemia in patients with human immunodeficiency virus infection. J Infect Dis. 1997;176(01):269–273. - PubMed
    1. Ashaka O S, Salu O B, James A B et al.Parvovirus B19 DNA detection in treatment-naïve HIV anemic patients in Lagos, Nigeria: a case control study. Afr Health Sci. 2020;20(01):219–226. - PMC - PubMed

LinkOut - more resources