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Review
. 2025 Mar 14:80:100617.
doi: 10.1016/j.clinsp.2025.100617. eCollection 2025.

Phyllodes tumors of the breast: A comprehensive review of diagnosis, treatment, and follow-up

Aline Rocha Donato  1 , Rodrigo Goncalves  2 , Jonathan Yugo Maesaka  3 , Fernando Nalesso Aguiar  4 , José Maria Soares Jr  1 , Carlos Alberto Ruiz  1 , José Roberto Filassi  3 , Edmund Chada Baracat  1
Affiliations
Review

Phyllodes tumors of the breast: A comprehensive review of diagnosis, treatment, and follow-up

Aline Rocha Donato et al. Clinics (Sao Paulo). .

Abstract

Phyllodes Tumor (PT) of the breast is a rare type of fibroepithelial neoplasm, classified into benign, borderline, and malignant subtypes. These tumors are known to be locally aggressive and have an inherent potential for Local Recurrence (LR), even after adequate surgical treatment. Establishing strategies to reduce LR has become increasingly important, as 21 % to 36 % of patients experience disease recurrence despite achieving negative surgical margins. Although surgical resection of the lesion is the gold standard treatment for all subtypes of phyllodes tumors, the ideal extent of the surgical margin remains a topic of debate with no consensus in the literature. Adjuvant radiotherapy is suggested as a tool to improve local control of the disease and reduce the recurrence rate; however, published data on this approach are currently conflicting. In this review paper, the authors will provide a detailed analysis of the current evidence on the diagnosis, treatment, follow-up, outcomes, and future perspectives of phyllodes tumors.

Keywords: Breast; Breast Diseases; Breast Neoplasms; Breast cancer; Fibrocystic breast disease; Phyllodes tumor.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflicts of interest.

Figures

Fig 1
Fig. 1
Histological Comparison of Fibroadenoma and Phyllodes Tumor Subtypes: Fibroadenoma (A), Benign Phyllodes Tumor (B), Borderline Phyllodes Tumor (C), and Malignant Phyllodes Tumor (D).
See this image and copyright information in PMC

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