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. 1985 Aug;135(2 Suppl):750s-754s.

Immune-neuroendocrine interactions

H O Besedovsky, A E del Rey, E Sorkin
  • PMID: 4008933

Immune-neuroendocrine interactions

H O Besedovsky et al. J Immunol. 1985 Aug.

Abstract

Concepts and facts concerning immune-neuroendocrine interactions are discussed. The immune response elicits endocrine, autonomic, and brain functional changes. These changes can be mediated by soluble factors released by activated immunologic cells. As a result of these immune-neuroendocrine interactions the content of powerful agents such as hormones, neurotransmitters, and neuropeptides in the microenvironment of immunologic cells is modified. This leads to external immunoregulatory signals imposed upon autoregulatory mechanisms.

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