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Review
. 2025 Mar;31(3S):S626-S634.
doi: 10.1016/j.jtct.2024.11.013.

The Clinical TIL Experience in Melanoma: Past, Present, Future

James W Smithy  1 , Adam J Schoenfeld  2 , Allison Betof Warner  3
Affiliations
Free article
Review

The Clinical TIL Experience in Melanoma: Past, Present, Future

James W Smithy et al. Transplant Cell Ther. 2025 Mar.
Free article

Abstract

The recent approval of lifileucel by the US Food and Drug Administration in February 2024 was the culmination of over 3 decades of research in adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) for unresectable melanoma. In this review, we highlight key historical data for TIL therapy in melanoma as well as ongoing efforts to improve its efficacy and applicability.

Keywords: Autologous; Immunotherapy; Melanoma; Tumor infiltrating lymphocytes.

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