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. 2025 May 29;145(22):2666-2670.
doi: 10.1182/blood.2024027034.

Impact of HLA alloimmunization in gene-modified autologous stem cell transplant for transfusion-dependent thalassemia

Nora M Gibson  1 , Eugene Khandros  2 , Caitlin W Elgarten  1 , Elizabeth Worster  1 , Dimitrios S Monos  3   4 , Alexis A Thompson  2 , Janet L Kwiatkowski  2 , Timothy S Olson  1
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Free article

Impact of HLA alloimmunization in gene-modified autologous stem cell transplant for transfusion-dependent thalassemia

Nora M Gibson et al. Blood. .
Free article

Abstract

We report our single-center experience demonstrating that HLA class I alloimmunization predicts longer time to platelet engraftment, increased bleeding complications, and higher transfusion requirements in patients undergoing gene-modified hematopoietic stem cell transplant for transfusion-dependent β thalassemia.

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