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. 2023 Dec;52(4):247-253.

Emergence of Raoultella ornithinolytica as a significant intestinal microbiota in Nigerian Neonates

B O Ogunbosi  1   2 , A Kigbu  2 , O O Tongo  1   2 , A A Adepoju  1   2 , A E Orimadegun  2   3 , G N Odaibo  4 , D O Olaleye  4 , O O Akinyinka  1   2
Affiliations

Emergence of Raoultella ornithinolytica as a significant intestinal microbiota in Nigerian Neonates

B O Ogunbosi et al. Afr J Med Med Sci. 2023 Dec.

Abstract
in English, French

Background: There are increasing reports of Raoultella ornithinolytica infection in humans. This study reports significant contribution of Raoultella ornithinolytica to neonatal gut microbiota.

Methods: Rectal swab samples were collected in 70 healthy neonates, within 6-12hours of birth, and days 3, 9, and 14 after birth. Colonization by R. ornithinolytica was evaluated against neonatal characteristics.

Results: Among the 70 neonates, R. ornithinolytica was the fourth most common bacteria isolated. R. ornithinolytica was part of gut microbiota at birth, and on Day 3, Day 9 and Day 14 after birth in 15%, 28.6%, 21.4% and 5.7% of neonates respectively. No factor was associated with R. ornithinolytica colonization, but a trend towards an increased likelihood of colonization among females, asphyxiated and neonates whose mothers had prolonged labour was observed.

Conclusion: R. ornithinolytica has emerged as an important part of gut microbiota among neonates in Nigeria, but its' role in neonatal dysbiosis and infection remains unclear.

Contexte: De plus en plus de cas d’infection à Raoultella ornithinolytica sont rapportés chez l’homme. Cette étude rapporte une contribution significative de Raoultella ornithinolytica au microbiote intestinal néonatal.

Méthodes: Des échantillons d’écouvillons rectaux ont été prélevés sur 70 nouveau-nés en bonne santé, dans les 6 à 12 heures suivant la naissance et les jours 3, 9 et 14 après la naissance. La colonisation par R. ornithinolytica a été évaluée par rapport aux caractéristiques néonatales.

Résultats: Parmi les 70 nouveau-nés, R. ornithinolytica était la quatrième bactérie la plus couramment isolée. R. ornithinolytica faisait partie du microbiote intestinal à la naissance et aux jours 3, 9 et 14 après la naissance chez 15 %, 28,6 %, 21,4 % et 5,7 % des nouveau-nés respectivement. Aucun facteur n’a été associé à la colonisation par R. ornithinolytica, mais une tendance à une probabilité accrue de colonisation chez les femelles, les asphyxiées et les nouveau-nés dont les mères ont eu un travail prolongé a été observée.

Conclusion: R. ornithinolytica est apparu comme une partie importante du microbiote intestinal chez les nouveau-nés au Nigeria, mais son rôle dans la dysbiose et l’infection néonatales reste incertain.

Keywords: Gut microbiota; Neonate; Raoultella ornithinolytica; infection.

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Figures

Fig 1:
Fig 1:
Pattern of bacterial colonization among the neonates
Fig 2:
Fig 2:
Trend of R. ornithinolytica colonization in the first 14 days of life among the neonates
See this image and copyright information in PMC

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