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Review
. 2025 Aug;17(4):2212-2226.
doi: 10.1007/s12602-025-10507-4. Epub 2025 Mar 17.

Lactic Acid Bacteria: A Probiotic to Mitigate Pesticide Stress in Honey Bee

Affiliations
Review

Lactic Acid Bacteria: A Probiotic to Mitigate Pesticide Stress in Honey Bee

Subramanian Pradeep et al. Probiotics Antimicrob Proteins. 2025 Aug.

Abstract

Using probiotics, especially those containing lactic acid bacteria (LAB), to support honey bee health and alleviate the negative effects of pesticides represents a promising approach for sustainable beekeeping. Probiotics have shown their ability to boost honey bee immune systems, counteract pesticide impacts, and lower disease rates. Bacteria like Lactobacillus and Bifidobacterium have demonstrated their ability to degrade organophosphorus pesticides using phosphatase enzymes. Additionally, these bacteria are resistant to the harmful effects of pesticides and aid in detoxification. Furthermore, supplementing with LAB positively affects colony growth, resulting in increased honey production, improved pollen storage, and higher brood counts. Various methods of delivering probiotics, such as powdered supplements, sucrose syrup, and pollen patties, have been explored, each with its own set of challenges and considerations. Despite making significant progress, further study is still required to fully comprehend the precise interactions between probiotics and the physiology of honey bees, to improve delivery strategies, and to evaluate the wider ecological effects on hive microbiomes. By implementing probiotic strategies in beekeeping practices, we can create stronger and more resilient honey bee colonies that can thrive amidst environmental challenges, thus promoting the sustainability of pollination services.

Keywords: Apiculture; Honey Bees; Lactic Acid Bacteria; Pesticide Stress; Probiotics.

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Conflict of interest statement

Declarations. Ethics Approval: Not applicable. Consent to Participate: Not applicable. Consent for Publication: Not applicable. Competing Interests: The authors declare no competing interests.

References

    1. Nabhan GP, Buchmann S (1997) The fraying web of life. In: World resources 2000–2001. UNDP, UNEP, WB, WRI, pp 136–138. https://doi.org/10.1016/B978-0-08-043781-1.X5000-2
    1. Kleijn D, Winfree R, Bartomeus I, Carvalheiro LG, Henry M, Isaacs R, Klein AM, Kremen C, M’Gonigle LK, Rader R, Ricketts TH, Williams NM, Lee Adamson N, Ascher JS, Báldi A, Batáry P, Benjamin F, Biesmeijer JC, Blitzer EJ et al (2015) Delivery of crop pollination services is an insufficient argument for wild pollinator conservation. Nat Commun 6:7414. https://doi.org/10.1038/ncomms8414 - DOI - PubMed
    1. Vanengelsdorp D, Meixner MD (2010) A historical review of managed honey bee populations in Europe and the United States and the factors that may affect them. J Invertebr Pathol 103(Suppl 1):S80–S95. https://doi.org/10.1016/j.jip.2009.06.011 - DOI - PubMed
    1. Vanengelsdorp D, Evan JD, Saegerman C, Mullin C, Haubruge E, Nguyen BK, Frazier M, Frazier J, Cox-Foster D, Chen Y, Underwood R, Tarpy DR, Pettis JS (2009) Colony collapse disorder: a descriptive study. PLoS One 4(8):e6481. https://doi.org/10.1371/journal.pone.0006481 - DOI - PubMed - PMC
    1. Wu Y, Zheng Y, Chen Y, Wang S, Chen Y, Hu F, Zheng H (2020) Honey bee (Apis mellifera) gut microbiota promotes host endogenous detoxification capability via regulation of P450 gene expression in the digestive tract. Microb Biotechnol 13(4):1201–1212. https://doi.org/10.1111/1751-7915.13579 - DOI - PubMed - PMC

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