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. 2025 Mar 1;14(5):1669.
doi: 10.3390/jcm14051669.

Fibrinogen-to-Albumin Ratio as Predictor of Mortality in Acute Aortic Syndromes

Alexandra Julia Lipa  1 , Patrick Andreikovits  1 , Marco Stoeckl  1 , Hans Domanovits  1 , Christian Schoergenhofer  2 , Michael Schwameis  1 , Juergen Grafeneder  1
Affiliations

Fibrinogen-to-Albumin Ratio as Predictor of Mortality in Acute Aortic Syndromes

Alexandra Julia Lipa et al. J Clin Med. .

Abstract

Background: Acute aortic syndrome (AAS) is a life-threatening condition characterized by a high mortality, yet reliable prognostic biomarkers are still lacking. The fibrinogen-to-albumin ratio (FAR) has recently gained attention in cardiovascular research but has not been explored in the context of AAS. This study assessed the association between the FAR and 30-day mortality in AAS patients who presented to the emergency department. Methods: We included all AAS patients aged 18 years and older who presented to the emergency department between 2013 and 2021. The outcome measured was 30-day all-cause mortality. Cox regression analysis assessed the relationship between the FAR and the outcome. Results: A total of 171 patients (mean age 67, SD 13.7; 33% female) were included, with 68 (40%) dying within 30 days of admission. Non-survivors had a significantly lower FAR (mean 8.9, SD 4.97) than survivors (mean 10.8, SD 5.44, p = 0.02). FAR was significantly associated with 30-day mortality (crude HR 0.935, 95% CI 0.88-0.99, p = 0.02). This association remained significant after adjusting for age, sex, cardiopulmonary resuscitation, catecholamine administration, bleeding on admission, and type of AAS (adjusted HR 0.92, 95% CI 0.87-0.98, p = 0.01). Conclusions: FAR was independently associated with 30-day mortality in AAS patients who presented to the emergency department. Given its simplicity and cost-effectiveness, it could be a valuable biomarker, especially in resource-limited settings, to improve risk assessment and optimize resource allocation in AAS.

Keywords: acute aortic syndrome; biomarkers; cardiovascular disease; emergency medicine.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram.
Figure 2
Figure 2
Kaplan–Meier curve categorized by fibrinogen-to-albumin ratio (FAR) quartiles.
See this image and copyright information in PMC

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