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Review
. 2025 Mar 17:8850666251320558.
doi: 10.1177/08850666251320558. Online ahead of print.

Multisystem Inflammatory Syndrome in Children: A Comprehensive Review Over the Past Five Years

Olivia Shyong  1   2 , Nora Alfakhri  1   2 , Sara V Bates  2   3 , Ryan W Carroll  1   2 , Krista Gallagher  1 , Lena Huang  4 , Vandana Madhavan  2   5 , Sarah A Murphy  1   2 , Sylvia A Okrzesik  6 , Phoebe H Yager  1   2 , Lael M Yonker  2   7 , Josephine Lok  1   2
Affiliations
Review

Multisystem Inflammatory Syndrome in Children: A Comprehensive Review Over the Past Five Years

Olivia Shyong et al. J Intensive Care Med. .

Abstract

Multisystem Inflammatory Syndrome in Children: A Comprehensive Review over the Past Five Years This review explores many facets of Multisystem Inflammatory Syndrome in Children (MIS-C) over the previous 5 years. In the time since the COVID 19 pandemic gripped our medical systems, we can now explore the data that has been collected from the previous years. The literature has allowed us to better understand the impact of COVID 19 and the post illness occurrence of a severe systemic inflammatory disease on our youngest patient populations. This paper will outline the pathophysiology of MIS-C, the treatments utilized, short and long-term patient outcomes including epidemiological factors.

Keywords: COVID-19; Cardiac; IVIG; Immune dysregulation; MIS-C; Multisystem Inflammatory Syndrome; Neutrophils; SARS-CoV2; critical care; glucocorticoids; inflammation; intensive care unit; outcomes; pediatrics.

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