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. 2025 Mar 17:ciaf120.
doi: 10.1093/cid/ciaf120. Online ahead of print.

Long-acting injectable HIV therapy outcomes among persons with HIV who have adherence challenges to oral antiretroviral therapy

Elizabeth Hastie  1 , Lucas Hill  1 , Laura Bamford  1 , Afsana Karim  1 , Thomas C S Martin  1   2
Affiliations

Long-acting injectable HIV therapy outcomes among persons with HIV who have adherence challenges to oral antiretroviral therapy

Elizabeth Hastie et al. Clin Infect Dis. .

Abstract

Long-acting injectable cabotegravir/rilpivirine (LAI-CAB/RPV) may improve outcomes among persons with HIV (PWH) with adherence difficulties to oral therapy. In this real-world observational study, over 85% of PWH with adherence difficulties remained on therapy and virally suppressed 48-weeks after initiating LAI-CAB/RPV. Providers should consider LAI therapy among PWH with adherence difficulties.

Keywords: Long-acting injectables; adherence challenges; cabotegravir-rilpivirine; people living with HIV; viremia.

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