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. 2025 Apr;10(4):836-840.
doi: 10.1038/s41564-025-01961-5. Epub 2025 Mar 17.

Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow's milk

Jeremy C Jones  1 , Konstantin Andreev  1 , Thomas P Fabrizio  1 , Andrew S Bowman  2 , Elena A Govorkova  1 , Richard J Webby  3
Affiliations

Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow's milk

Jeremy C Jones et al. Nat Microbiol. 2025 Apr.

Erratum in

Abstract

Testing approved antivirals against A(H5N1) influenza viruses circulating in peridomestic species, including dairy cows, is critical to public health and pre-pandemic planning. It cannot be tested in humans due to A(H5N1) disease severity. Here, in mice, we demonstrate that US FDA-approved baloxavir treatment mediates improved disease outcomes (survival and viral dissemination) over oseltamivir after lethal intranasal and ocular challenge with A(H5N1)-contaminated cow milk.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

References

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