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. 2025 Mar 12:18:1473-1482.
doi: 10.2147/JMDH.S487479. eCollection 2025.

Risk Factors for Cognitive Impairment Following Angiographically Negative Subarachnoid Haemorrhage Around the Midbrain

Yingfeng Liu  1 , Zhong Li  1 , Wende Xu  1 , Ziyu Zhao  1 , Wei Zhang  1 , Junlong Wu  1
Affiliations

Risk Factors for Cognitive Impairment Following Angiographically Negative Subarachnoid Haemorrhage Around the Midbrain

Yingfeng Liu et al. J Multidiscip Healthc. .

Abstract

Objective: This study aimed to explore the risk factors for cognitive impairment caused by angiographically negative subarachnoid haemorrhage (SAH).

Methods: This retrospective study employed a convenience sampling method to select patients with negative SAH in the midbrain who were admitted to the neurosurgery department of our hospital between September 2018 and September 2023. A total of 69 patients with angiographically negative SAH were enrolled and divided into the cognitive impairment group (n = 16) and the non-cognitive impairment group (n = 53). General demographic and clinical data were collected, and patients' cognitive function was assessed using the Montreal Cognitive Assessment scale. The risk factors of the cognitive impairment caused by angiographically negative SAH were identified by logistic regression analysis.

Results: The results of the univariate analysis showed that there were statistically significant differences (p < 0.05) between the two groups of patients in terms of age, consciousness disorders, history of hypertension, ventricular haemorrhage, concurrent hydrocephalus, Glasgow Coma Scale score, Hunt-Hess grading (≥3) and Fisher grading (≥3). The logistic regression results showed that age (p = 0.031), degree of consciousness impairment (p = 0.023), Hunt-Hess grading (p = 0.019), presence of hydrocephalus (p = 0.002) and presence of ventricular haemorrhage (p = 0.021) were independent risk factors for cognitive impairment after angiographically negative SAH (p < 0.05).

Conclusion: Age, degree of consciousness impairment, Hunt-Hess grade (≥3), concomitant ventricular haemorrhage and hydrocephalus are risk factors for cognitive function after angiographically negative SAH.

Keywords: cognitive impairment; computed tomography angiography; digital subtraction angiography; subarachnoid haemorrhage.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The flowchart.
Figure 2
Figure 2
Imaging data of ventricular hemorrhage. CT showed negative SAH around the midbrain, hemorrhage ruptured into the ventricles, and ventricular hematocele.
Figure 3
Figure 3
Imaging data of hydrocephalus. CT showed SAH around the midbrain, in the lateral fissure, hemorrhage ruptured into the ventricles, ventriculomegaly, and obstructive hydrocephalus formation.
See this image and copyright information in PMC

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