The predictive nature of spontaneous brain activity across scales and species

Abstract

Emerging research suggests the brain operates as a "prediction machine," continuously anticipating sensory, motor, and cognitive outcomes. Central to this capability is the brain's spontaneous activity-ongoing internal processes independent of external stimuli. Neuroimaging and computational studies support that this activity is integral to maintaining and refining mental models of our environment, body, and behaviors, akin to generative models in computation. During rest, spontaneous activity expands the variability of potential representations, enhancing the accuracy and adaptability of these models. When performing tasks, internal models direct brain regions to anticipate sensory and motor states, optimizing performance. This review synthesizes evidence from various species, from C. elegans to humans, highlighting three key aspects of spontaneous brain activity's role in prediction: the similarity between spontaneous and task-related activity, the encoding of behavioral and interoceptive priors, and the high metabolic cost of this activity, underscoring prediction as a fundamental function of brains across species.

Keywords: behavioral priors; metabolic priors; predictive brains; spontaneous brain activity; task-rest similarity.