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Review
. 2025 Mar 18;20(1):39.
doi: 10.1186/s13020-025-01087-0.

Reunderstanding the classical prescription Banxia Xiexin Decoction: new perspectives from a comprehensive review of clinical research and pharmacological studies

Chang Liu #  1   2 , Pengwei Gao #  1 , Xiaoying Liu  1 , Min Kuang  3   4 , Haoran Xu  3   4 , Yangming Wu  3   4 , Wenjun Liu  5   6 , Shengpeng Wang  7   8
Affiliations
Review

Reunderstanding the classical prescription Banxia Xiexin Decoction: new perspectives from a comprehensive review of clinical research and pharmacological studies

Chang Liu et al. Chin Med. .

Abstract

Classical prescriptions of Chinese medicine represent the crystallized wisdom of millennia of clinical practice, enduring as cornerstones of therapeutic intervention due to their demonstrated efficacy across generations. Their evolving role in modern healthcare systems reflects shifting disease patterns, scientific advancements, and global health priorities. Banxia Xiexin Decoction (BXD), formulated by Zhang Zhongjing in the Treatise on Febrile and Miscellaneous Diseases (Shanghanlun), is a time-honored classical prescription renowned for its therapeutic versatility in managing gastrointestinal disorders, both in China and internationally. Recent advancements in clinical research and pharmacological studies on BXD underscore the necessity for a comprehensive bibliometric analysis to summarize and elucidate its specific clinical benefits. Through an extensive literature review of publications from the Web of Science, PubMed, Scopus, and the China National Knowledge Infrastructure (CNKI) between 1997 and 2024, 11 major categories of clinical applications for BXD were identified, along with an analysis of the potential pharmacological mechanisms, such as chronic gastritis, functional dyspepsia, and inflammatory bowel disease. We believe this review will provide new insights into the understanding of clinical value of BXD and identify potential future perspectives for its research and development.

Keywords: Banxia Xiexin Decoction; Bibliometric analysis; Classical prescription; Gastric ulcer; Gastritis.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare that there are no competing interests.

Figures

Fig. 1
Fig. 1
Seven Chinese herbal medicines comprising BXD and their representative compounds. Representative active compounds of Pinelliae Rhizoma (A), Coptidis Rhizoma (B), Scutellariae Radix (C), Zingiberis Rhizoma (D), Glycyrrhizae Radix et Rhizoma (E), Jujubae Fructus (F), and Ginseng Radix et Rhizoma (G)
Fig. 2
Fig. 2
Screening process for publications of BXD using CNKI, WoS, PubMed, and Scopus databases
Fig. 3
Fig. 3
A Annual number of BXD-related publications retrieved from CNKI, WoS, PubMed, and Scopus; B keywords with the strongest citation burst among BXD-related publications indexed in WoS, PubMed, and Scopus; C keywords with the strongest citation burst among BXD-related publications indexed in CNKI
Fig. 4
Fig. 4
Country network and co-occurrence analysis of BXD studies in WoS, PubMed, and Scopus. A Global research landscape for BXD. B Author co-occurrence analysis of BXD
Fig. 5
Fig. 5
A Clusters of number of cited references. B Clusters of number of most cited authors
Fig. 6
Fig. 6
Screening process of the clinical application publications of BXD from CNKI
Fig. 7
Fig. 7
Screening process of the clinical application publications of BXD from WoS, PubMed and Scopus
Fig. 8
Fig. 8
Classification of clinical application of BXD
Fig. 9
Fig. 9
Clinical application of BXD and related mechanism
See this image and copyright information in PMC

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