Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2025 Mar 18;18(1):116.
doi: 10.1186/s13104-025-07116-3.

The effect of povidone-iodine 10% plus levofloxacin 0.5% before cataract surgery: a randomized clinical trial

Ali Azimi  1 , Mohammad Reza Jafari  2 , Ehsan Namvar  3 , Nasrin Masihpour  4 , Shadi Meshksar  2
Affiliations
Randomized Controlled Trial

The effect of povidone-iodine 10% plus levofloxacin 0.5% before cataract surgery: a randomized clinical trial

Ali Azimi et al. BMC Res Notes. .

Abstract

This study was designed to assess the efficacy of using povidone-iodine (PVI) 10% and levofloxacin 0.5% about one hour before cataract surgery in minimizing aqueous contamination compared with using PVI 10%. The intervention group received three drops of mixed povidone-iodine and levofloxacin (PVI/Levofloxacin) solution one hour before surgery. After making the corneal incision in cataract surgery, 0.1 cc aqueous humor sample was taken and sent for culture. We compared the intervention group and control group using t-test and chi-square test in SPSS 25(Chicago IL, USA). 147 eyes of 147 patients were analyzed. The intervention and control groups consisted of 72 and 75 patients, respectively. The Control group showed significantly more positive cultures (16 cultures: 22.2%). the intervention group had four positive cultures (5.3%). (P-value = 0.005). Topical levofloxacin 0.5% and povidone-iodine 10% mixture showed promising results in reducing the number of bacteria in the aqueous humor.

Keywords: Endophthalmitis; Levofloxacin; Povidone-iodine.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: All methods and experimental protocols were under the tenets of the Declaration of Helsinki and approved by the ethics committee of Shiraz University of Medical Sciences and the Iranian Registry of Clinical Trials (IR.SUMS.MED.REC.1398.610 and IRCT20191023045211N1). Consent to participate was obtained from the patients. Consent for publication: Not applicable. Informed consent: All participants were informed about the interventions, and written informed consents were obtained. Trial registration: This study was a randomized clinical trial that approved by Iranian Registry of Clinical Trials (IRCT20191023045211N1) on 30th March 2023. Source of support: This study was supported by Shiraz University of Medical Sciences and the grant number is 18,707. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The CONSORT diagram showing the allocation process throughout the trial
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Fan C, Yang B, Huang Y. Efficacy of 0.5% levofloxacin and 5.0% povidone-iodine eyedrops in reducing conjunctival bacterial flora: metagenomic analysis. Journal of ophthalmology. 2020;2020. - PMC - PubMed
    1. Peyman A, Hosseini M, Narimani T. Comparison of the effects of povidone-iodine 5%, polyhexamethylene biguanide, and chlorhexidine as a preoperative antiseptic in endophthalmitis prophylaxis in patients undergoing phacoemulsification cataract surgery. Adv Biomedical Res. 2020;9. - PMC - PubMed
    1. Grzybowski A, Shimada H, Nakashizuka H, Koerner J. Low-concentration povidone-iodine for the prevention of intraocular infections in ophthalmic surgery. Curr Opin Ophthalmol. 2022;33(1):28–34. - PubMed
    1. Grzybowski A, Turczynowska M. Prophylaxis and Treatment of Endophthalmitis. Cataract Surgery: Springer; 2021. pp. 191–9.
    1. Nentwich MM, Ta CN, Kreutzer TC, Li B, Schwarzbach F, Yactayo-Miranda YM, et al. Incidence of postoperative endophthalmitis from 1990 to 2009 using povidone–iodine but no intracameral antibiotics at a single academic institution. J Cataract Refractive Surg. 2015;41(1):58–66. - PubMed

Publication types

LinkOut - more resources