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Review
. 2025 Mar 4:16:1464498.
doi: 10.3389/fphar.2025.1464498. eCollection 2025.

The potential of Sijunzi decoction in the fight against gastrointestinal disorders: a review

Liangjun Yang #  1 , Zheng Fang  1 , Jiajie Zhu  1 , Xiaofang Li  2 , Bo Yang  3 , Haiyan Liu  1 , Feiyan Lou  4
Affiliations
Review

The potential of Sijunzi decoction in the fight against gastrointestinal disorders: a review

Liangjun Yang et al. Front Pharmacol. .

Abstract

Sijunzi Decoction (SJZD) is a traditional Chinese medicine formula widely used in the treatment of gastrointestinal disorders. Clinical studies have substantiated the efficacy of SJZD in managing conditions such as functional dyspepsia, chronic gastritis, gastric cancer, irritable bowel syndrome, colorectal cancer, and ulcerative colitis. Despite its proven effectiveness, the precise mechanisms by which SJZD operates remain incompletely understood. In this study, we undertake a systematic review of both the clinical applications and the mechanistic underpinnings of SJZD in the context of gastrointestinal disease treatment. Research indicates that SJZD functions through a spectrum of mechanisms including the regulation of intestinal flora, alleviation of inflammation, modulation of immune responses, and facilitation of mucosal repair in the treatment of gastrointestinal ailments. This comprehensive analysis aims to provide a clearer understanding of how SJZD benefits patients with gastrointestinal disorders.

Keywords: Sijunzi decoction (SJZD); functional dyspepsia; gastrointestinal disorders; irritable bowel syndrome; traditional Chinese; tumor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The mechanism of action of SJZD in the treatment of gastrointestinal disorders.
See this image and copyright information in PMC

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