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Case Reports
. 2025 Feb 26:58:101708.
doi: 10.1016/j.gore.2025.101708. eCollection 2025 Apr.

Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response

Madeline Petty  1 , Vasanti Jhaveri  2 , Nicholas Taylor  2 , Benjamin Foster  3
Affiliations
Case Reports

Oligometastatic granulosa cell tumor treated with stereotactic body radiation therapy with a radiographic and tumor marker response

Madeline Petty et al. Gynecol Oncol Rep. .

Abstract

Stereotactic body radiation therapy (SBRT) is a safe and effective treatment for oligometastatic gynecologic cancers. This report details the case of a 75-year-old woman with recurrent granulosa cell tumor of the left ovary. The patient was diagnosed with a peritoneal recurrence after her inhibin-B level increased to 39.7 pg/mL, and a subsequent computed tomography (CT) scan of the abdomen and pelvis revealed an enlarging left-sided soft tissue mass in the sigmoid mesentery measuring 1.2 × 1.2 cm. She underwent SBRT, delivering 37.5 Gy in 5 fractions to the soft tissue mass. A CT scan post-treatment indicated the mass had decreased to 0.8 cm and that her inhibin B level decreased to < 7 pg/mL. This case highlights the effectiveness of SBRT in the management of oligometastatic ovarian cancer, achieving a marked radiographic and tumor marker response in patients with disease not amenable to surgical resection.

Keywords: Granulosa cell tumor; Inhibin B; Stereotactic body radiation therapy.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
CT Image of Peritoneal Implant Prior to SBRT.
Fig. 2
Fig. 2
CT Image After Completion of SBRT showing a Partial Response.
See this image and copyright information in PMC

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