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. 2025 Mar 4:7:1472753.
doi: 10.3389/fdgth.2025.1472753. eCollection 2025.

Global research landscape on nanotechnology in acute lung injury: a bibliometric analysis

Jian Zhang #  1   2 , Shasha Jiang  2   3 , Jipeng Jiang #  2 , Yang Liu #  1   2
Affiliations

Global research landscape on nanotechnology in acute lung injury: a bibliometric analysis

Jian Zhang et al. Front Digit Health. .

Abstract

Background: Acute lung injury is a common respiratory emergency that seriously affects the life, health and quality of life of patients, especially after the global COVID-19 pneumonia. The application of nanotechnology in acute lung injury is promising. In response to the knowledge explosion resulting from rapid publication growth, we applied bibliometric analysis to explore the research profile and thematic trends in the field.

Methods: Articles and reviews related to nanotechnology in acute lung injury from 2004 to 2023 were searched. Java-based Citespace, VOSviewer, and R software-based Bibiometrix were used to systematically evaluate publications by spatiotemporal distribution, author distribution, subject categories, topic distribution, references, and keywords.

Results: A total of 1,347 publications were included. The number of papers related to nanotechnology in acute lung injury has grown exponentially over the past 20 years. China was the most productive country out of all 53 countries, followed by the United States. The Chinese Academy of Sciences was the most productive institution with 76 papers. PARTICLE AND FIBRE TOXICOLOGY was the most productive journal. The top five high-frequency keywords were inflammation, oxidative stress, toxicity, in vitro, respiratory-distress-syndrome. And the top five emerging keywords were delivery, covid-19, extracellular vesicles, therapy, sars-cov-2. Drug delivery are the focus of current research. Two emerging research areas represented the development trends: novel nanocarriers with higher efficiency and lower biotoxicity, and the other is research related to impact of nanomaterials in the progression of acute lung injury.

Conclusion: The field of nanotechnology in acute lung injury has been in a period of rapid development in the last three years. Delivery,targeted delivery and exosm have been the focus of current research in this field. Two emerging research areas represented the development trends:novel nanocarriers with higher efficiency and lower biotoxicity such as extracellular vesicles, exosomes and solid lipid nanoparticles, and the other is research related to impact of nanomaterials in the progression of acute lung injury.

Keywords: acute lung injury; bibliometric analysis; drug delivery; nanotechnology; research trend.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Annual publication trends in the world (A) and in the top ten most productive countries (B).
Figure 2
Figure 2
The country distribution (A) and international collaboration (B) of publications in the field of nanotechnology in acute lung injury.
Figure 3
Figure 3
Publication performance of the institution: the top ten most productive institutions (A); inter-institutional collaboration network (B); and co-authorship analysis of institutions (C).
Figure 4
Figure 4
Publication performance of the authors: the inter-author collaboration network (A); and top authors’ production over time (B).
Figure 5
Figure 5
Publication performance of the journals: co-citation network (A); and density visualization (B).
Figure 6
Figure 6
A dual-map overlap of the research journals.
Figure 7
Figure 7
Highly contributive papers: a co-citation network (A) and density visualization (B) of references; and the top 20 references with the strongest citation bursts (C).
Figure 8
Figure 8
Cluster analysis (A), temporal evolution (B), and trends (C) of the keywords.
Figure 9
Figure 9
Burst detection of the keywords.
See this image and copyright information in PMC

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