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. 2025 Mar 17;13(3):e70315.
doi: 10.1002/ccr3.70315. eCollection 2025 Mar.

Association of Bullous Lichen Sclerosus and Morphea

Seyyede Zeinab Azimi  1 , Fatemeh Sari Aslani  2 , Mohammad Mahdi Parvizi  3 , Mohammad Reza Namazi  3   4
Affiliations

Association of Bullous Lichen Sclerosus and Morphea

Seyyede Zeinab Azimi et al. Clin Case Rep. .

Abstract

Lichen sclerosus (LSc) is an inflammatory skin disease of unknown etiology. The coexistence of LSc and morphea in the same lesion is uncommon but exists. Also, there exist a few rare cases of bullous LSc-generalized morphea overlap syndrome.

Keywords: breast cancer; bullous; lichen sclerosus; morphea.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Large, intensely indurated plaques with white areas on the buttock (A) and abdomen (B).
FIGURE 2
FIGURE 2
Bullous lesions on the patient's morphea plaques.
FIGURE 3
FIGURE 3
There is hyperkeratosis, thinning of the epidermis, severe papillary dermal edema (arrow), hemorrhage, subepidermal bulla, homogenization of collagen fibers, and prominent thin‐walled vessels (A). The reticular dermis shows thickening of collagen bundles (arrow) with perieccrine fat replacement (arrow head) (B) and mild perivascular lymphocyte and plasma cell infiltration (arrow) (C). (H&E ×100 & 400).
See this image and copyright information in PMC

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