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Case Reports
. 2025 Feb 28;12(1):100167.
doi: 10.1016/j.acpath.2025.100167. eCollection 2025 Jan-Mar.

Educational Case: Essential thrombocythemia

David T Danielson  1 , Jeannie M Muir  1   2
Affiliations
Case Reports

Educational Case: Essential thrombocythemia

David T Danielson et al. Acad Pathol. .
No abstract available

Keywords: Essential thrombocythemia; Hematopathology; Myeloid neoplasia; Organ system pathology; Pathology competencies; Primary myelofibrosis; White cell disorders.

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Conflict of interest statement

No conflicting relationship exists for any author.

Figures

Fig. 1
Fig. 1
Wright-Giemsa staining of the aspirate demonstrates trilineage hematopoiesis with abnormal megakaryocytes. (A–C) Frequent large and hyperlobated megakaryocytes are present some of which have a vaguely “staghorn” appearing nuclei (original magnification, ×400). (D) Occasional hypolobated megakaryocytes are appreciated (original magnification, ×400).
Fig. 2
Fig. 2
(A) H&E staining of the bone marrow biopsy demonstrates an increase in megakaryocytes, some of which demonstrate hyperlobation. The megakaryocytes are distributed throughout the sample with occasional loose clumping (original magnification, ×200). (B) H&E staining of the bone marrow biopsy demonstrating hyperlobation (arrow; original magnification, ×400. (C) Special staining for reticulin does not demonstrate increased reticulin deposition within the bone marrow (original magnification, ×200). (D) Special staining for collagen (trichrome) does not demonstrate increased collagen deposition within the bone marrow (original magnification, ×200). H&E: hematoxylin and eosin.
Fig. 3
Fig. 3
(A) CD3 immunohistochemical stain highlights scattered small T-cells (original magnification, ×200). (B) CD20 immunohistochemical stain highlights scattered small B-cells (original magnification, ×200). (C) CD34 immunohistochemical stain highlights scattered progenitor cells and endothelial cells. The precursor cells make up an estimated 1% of the overall cellularity (original magnification, ×200). (D) CD61 immunohistochemical stain highlights numerous megakaryocytes, which are scattered individually and in loose clusters (original magnification, ×200).
See this image and copyright information in PMC

References

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