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Review
. 2025 Mar 4:15:1548036.
doi: 10.3389/fonc.2025.1548036. eCollection 2025.

A case of high-grade adenosquamous carcinoma of the breast: case report and literature review

Xiaoxiao Xing  1 , Junyi Li  1 , Yangyang Fan  2 , Yun Wang  3 , Yue Wang  1 , Daixiang Liao  1 , Shiyun Zhang  1
Affiliations
Review

A case of high-grade adenosquamous carcinoma of the breast: case report and literature review

Xiaoxiao Xing et al. Front Oncol. .

Abstract

High-grade adenosquamous carcinoma (HGASC) is a rare and aggressive subtype of metaplastic breast cancer (MpBC). This article reports a case of HGASC (pT2N0M0 Stage IIA) in a 43-year-old female and reviews the relevant literature, with a specific focus on distinguishing HGASC from other MpBC subtypes, particularly low-grade adenosquamous carcinoma (LGASC). The patient underwent a skin-sparing mastectomy with abdominal rectus myocutaneous flap reconstruction. Histopathology confirmed HGASC with metaplastic features. Postoperative adjuvant chemotherapy with capecitabine was administered. The case highlights the unique clinical, imaging, and pathological characteristics of HGASC, its therapeutic challenges, and the need for individualized treatment strategies. A five-month follow-up showed no signs of recurrence or metastasis.

Keywords: adjuvant chemotherapy; breast cancer surgery; case report; high-grade adenosquamous carcinoma; metaplastic breast cancer.

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Conflict of interest statement

All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
MRI Findings: T1WI (A), T2WI (B), T1WI+Contrast (C), DWI (D), DCE-Curve (E).
Figure 2
Figure 2
Perineural Invasion (A) and Immunohistochemistry: Ki-67 (B), ER (C), PR (D), HER-2 (E) and AR (F).
See this image and copyright information in PMC

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