Osimertinib for uncommon EGFR mutations: herding UNICORNs in a field of horses
- PMID: 40104749
- PMCID: PMC11912071
- DOI: 10.21037/tcr-24-1936
Osimertinib for uncommon EGFR mutations: herding UNICORNs in a field of horses
Keywords: Non-small cell lung cancer (NSCLC); epidermal growth factor receptor (EGFR); osimertinib mesylate; tyrosine kinase inhibitor (TKI).
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-24-1936/coif). R.D.G. reports the following conflicts of interest for the prior 3 years: research funding to institution from Pfizer, Tempus, Nalo Therapeutics, Puma, Mirati, Bristol Myers Squibb, Dizal, Chugai, Amgen, AstraZeneca, Janssen, Daiichi Sankyo, Jounce Therapeutics, Takeda, Merck, Alliance Foundation, ECOG/ACRIN, NCI, Big Ten Research Consortium, Hoosier Cancer Research Network, and SWOG; Honoraria from Bio Ascend, Academy for Continued Healthcare Learning, Curio, OncLive, Aptitude Health, MedStar Health, Clinical Care Options, Society for Immunotherapy of Cancer (SITC) and American Society of Clinical Oncology; Travel support to meetings from Dava Oncology, Tempus, American Society of Clinical Oncology (ASCO), and International Association for the Study of Lung Cancer (IASLC); Consulting fees from Amgen, Genentech, AstraZeneca, Regeneron, Merus, Takeda, Gilead, Janssen; and Leadership roles with Hoosier Cancer Research Network, ASCO, Journal of Clinical Oncology, NCI Investigational Drug Steering Committee, and IASLC Conference Planning Committees. The other author has no conflicts of interest to declare.
Comment on
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First-Line Osimertinib for Previously Untreated Patients With NSCLC and Uncommon EGFR Mutations: The UNICORN Phase 2 Nonrandomized Clinical Trial.JAMA Oncol. 2024 Jan 1;10(1):43-51. doi: 10.1001/jamaoncol.2023.5013. JAMA Oncol. 2024. PMID: 37991747 Free PMC article.
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