Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Feb 13;16(3):373-374.
doi: 10.1021/acsmedchemlett.5c00047. eCollection 2025 Mar 13.

Novel Tryptamine Compounds as 5-HT2A Agonists for Treating Mood Disorders such as Depressive Disorders and Bipolar Disorders

Ram W Sabnis  1 , Anika R Sabnis  2
Affiliations
Editorial

Novel Tryptamine Compounds as 5-HT2A Agonists for Treating Mood Disorders such as Depressive Disorders and Bipolar Disorders

Ram W Sabnis et al. ACS Med Chem Lett. .

Abstract

Provided herein are novel tryptamine compounds as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating mood disorders such as depressive disorders and bipolar disorders and processes for preparing such compounds.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interest.

References

    1. Duan W.; Cao D.; Wang S.; Cheng J. Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants. Chem. Rev. 2024, 124, 124–163. 10.1021/acs.chemrev.3c00375. - DOI - PubMed
    1. Miranda L. Antidepressant and anxiolytic effects of activating 5HT2A receptors in the anterior cingulate cortex and the theoretical mechanisms underlying them—A scoping review of available literature. Brain Res. 2025, 1846, 149226.10.1016/j.brainres.2024.149226. - DOI - PubMed
    1. Glennon R. A.; Dukat M. 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI): From an Obscure to Pivotal Member of the DOX Family of Serotonergic Psychedelic Agents—A Review. ACS Pharmacol. Transl. Sci. 2024, 7, 1722–1745. 10.1021/acsptsci.4c00157. - DOI - PMC - PubMed
    1. Korkmaz N. D.; Cikrikcili U.; Akan M.; Yucesan E. Psychedelic therapy in depression and substance use disorders. Eur. J. Neurosci. 2024, 60, 4063–4077. 10.1111/ejn.16421. - DOI - PubMed
    1. Sabnis R. W. Novel 3-Pyrrolidineindole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis and Mental Illnesses Such as Depression and Post-Traumatic Stress Disorder. ACS Med. Chem. Lett. 2025, 16, 18–19. 10.1021/acsmedchemlett.4c00581. - DOI - PMC - PubMed

Publication types

LinkOut - more resources