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Editorial
. 2025 Mar 13;16(3):356-357.
doi: 10.1021/acsmedchemlett.5c00001.

Identification of Phosphodiesterase-7 Inhibitors with Spiro[[1,3]oxazolo[5,4- f]quinazoline-9,1'-cyclohexan]-7-one Scaffold for the Treatment of Chronic Fatigue

Zhendong Song  1 , Steven H Liang  1
Affiliations
Editorial

Identification of Phosphodiesterase-7 Inhibitors with Spiro[[1,3]oxazolo[5,4- f]quinazoline-9,1'-cyclohexan]-7-one Scaffold for the Treatment of Chronic Fatigue

Zhendong Song et al. ACS Med Chem Lett. .

Abstract

The invention in this patent relates to the use of phosphodiesterase-7 (PDE7) inhibitors with a spiro[[1,3]oxazolo[5,4-f]quinazoline-9,1'-cyclohexan]-7-one scaffold for the treatment and prevention of diseases and syndromes associated with chronic fatigue, exhaustion, and exertional intolerance.

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Conflict of interest statement

The authors declare no competing financial interest.

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References

    1. Huang J. X.; Zhu B. L.; Xu J. P.; Zhou Z. Z. Advances in the development of phosphodiesterase 7 inhibitors. Eur. J. Med. Chem. 2023, 250, 115194.10.1016/j.ejmech.2023.115194. - DOI - PubMed
    1. Zorn A.; Baillie G. Phosphodiesterase 7 as a therapeutic target - Where are we now?. Cell Signal 2023, 108, 110689.10.1016/j.cellsig.2023.110689. - DOI - PubMed
    1. Nourian Y. H.; Salimian J.; Ahmadi A.; Salehi Z.; Karimi M.; Emamvirdizadeh A.; Azimzadeh Jamalkandi S.; Ghanei M. cAMP-PDE signaling in COPD: Review of cellular, molecular and clinical features. Biochem. Biophys. Rep. 2023, 34, 101438.10.1016/j.bbrep.2023.101438. - DOI - PMC - PubMed
    1. Khan H.; Tiwari C.; Grewal A. K.; Singh T. G.; Chauhan S.; Batiha G. E. Pharmacological modulation of phosphodiesterase-7 as a novel strategy for neurodegenerative disorders. Inflammopharmacology 2022, 30 (6), 2051–2061. 10.1007/s10787-022-01072-1. - DOI - PubMed
    1. Chen Y.; Wang H.; Wang W. Z.; Wang D.; Skaggs K.; Zhang H. T. Phosphodiesterase 7(PDE7): A unique drug target for central nervous system diseases. Neuropharmacology 2021, 196, 108694.10.1016/j.neuropharm.2021.108694. - DOI - PubMed

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