Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Mar 13;16(3):356-357.
doi: 10.1021/acsmedchemlett.5c00001.

Identification of Phosphodiesterase-7 Inhibitors with Spiro[[1,3]oxazolo[5,4- f]quinazoline-9,1'-cyclohexan]-7-one Scaffold for the Treatment of Chronic Fatigue

Zhendong Song  1 , Steven H Liang  1
Affiliations
Editorial

Identification of Phosphodiesterase-7 Inhibitors with Spiro[[1,3]oxazolo[5,4- f]quinazoline-9,1'-cyclohexan]-7-one Scaffold for the Treatment of Chronic Fatigue

Zhendong Song et al. ACS Med Chem Lett. .

Abstract

The invention in this patent relates to the use of phosphodiesterase-7 (PDE7) inhibitors with a spiro[[1,3]oxazolo[5,4-f]quinazoline-9,1'-cyclohexan]-7-one scaffold for the treatment and prevention of diseases and syndromes associated with chronic fatigue, exhaustion, and exertional intolerance.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interest.

References

    1. Huang J. X.; Zhu B. L.; Xu J. P.; Zhou Z. Z. Advances in the development of phosphodiesterase 7 inhibitors. Eur. J. Med. Chem. 2023, 250, 115194.10.1016/j.ejmech.2023.115194. - DOI - PubMed
    1. Zorn A.; Baillie G. Phosphodiesterase 7 as a therapeutic target - Where are we now?. Cell Signal 2023, 108, 110689.10.1016/j.cellsig.2023.110689. - DOI - PubMed
    1. Nourian Y. H.; Salimian J.; Ahmadi A.; Salehi Z.; Karimi M.; Emamvirdizadeh A.; Azimzadeh Jamalkandi S.; Ghanei M. cAMP-PDE signaling in COPD: Review of cellular, molecular and clinical features. Biochem. Biophys. Rep. 2023, 34, 101438.10.1016/j.bbrep.2023.101438. - DOI - PMC - PubMed
    1. Khan H.; Tiwari C.; Grewal A. K.; Singh T. G.; Chauhan S.; Batiha G. E. Pharmacological modulation of phosphodiesterase-7 as a novel strategy for neurodegenerative disorders. Inflammopharmacology 2022, 30 (6), 2051–2061. 10.1007/s10787-022-01072-1. - DOI - PubMed
    1. Chen Y.; Wang H.; Wang W. Z.; Wang D.; Skaggs K.; Zhang H. T. Phosphodiesterase 7(PDE7): A unique drug target for central nervous system diseases. Neuropharmacology 2021, 196, 108694.10.1016/j.neuropharm.2021.108694. - DOI - PubMed

Publication types

LinkOut - more resources