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Editorial
. 2025 Jan 23;16(3):358-360.
doi: 10.1021/acsmedchemlett.5c00013. eCollection 2025 Mar 13.

Hydroquinazoline Derivatives as Novel Natriuretic Peptide Receptor 1 (NPR1) Activators

Xin Zhou  1 , Steven H Liang  1
Affiliations
Editorial

Hydroquinazoline Derivatives as Novel Natriuretic Peptide Receptor 1 (NPR1) Activators

Xin Zhou et al. ACS Med Chem Lett. .

Abstract

This patent highlights hydroquinazoline compounds and their pharmaceutically acceptable salts, as well as compositions and methods of preparation. The compounds in this invention were evaluated for their potency on Natriuretic Peptide Receptor 1 (NPR1), a receptor guanylate cyclase known to play a critical role in lowering blood pressure and blood volume.

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Conflict of interest statement

The authors declare no competing financial interest.

References

    1. Giovou A. E.; Gladka M. M.; Christoffels V. M. The Impact of Natriuretic Peptides on Heart Development, Homeostasis, and Disease. Cells 2024, 13 (11), 931.10.3390/cells13110931. - DOI - PMC - PubMed
    1. Dickinson Y. A.; Moyes A. J.; Hobbs A. J. C-type natriuretic peptide (CNP): The cardiovascular system and beyond. Pharmacol Ther 2024, 262, 108708.10.1016/j.pharmthera.2024.108708. - DOI - PubMed
    1. Haghighat L.; DeJong C.; Teerlink J. R. New and future heart failure drugs. Nat. Cardiovasc Res. 2024, 3 (12), 1389–1407. 10.1038/s44161-024-00576-z. - DOI - PubMed
    1. Mishra S.; Chander V.; Kass D. A. Cardiac cGMP Regulation and Therapeutic Applications. Hypertension 2025, 82, 185–196. 10.1161/HYPERTENSIONAHA.124.21709. - DOI - PMC - PubMed
    1. De la Sierra A.; Oliveras A. New therapeutic targets in hypertension. Medicina Clínica (English Edition) 2024, 163 (6), 301–305. 10.1016/j.medcle.2024.03.025. - DOI - PubMed

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