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Review
. 2024 Dec 31;16(3):379-387.
doi: 10.1021/acsmedchemlett.4c00568. eCollection 2025 Mar 13.

Is a Fungal Apocalypse Inevitable or Just a Hallucination? An Overview of the Antifungal Armamentarium Used in the Fight against Pathogenic Fungi

Doaa M Hanafy  1 , David J Leaver  1
Affiliations
Review

Is a Fungal Apocalypse Inevitable or Just a Hallucination? An Overview of the Antifungal Armamentarium Used in the Fight against Pathogenic Fungi

Doaa M Hanafy et al. ACS Med Chem Lett. .

Abstract

The World Health Organization (WHO) fungal priority pathogens list (WHO FPPL) published in 2022 highlighted the inequity and research challenges faced by researchers who study pathogenic fungi that afflict humans. Antifungal drugs are the only weapon available to treat infections; however, these drugs are old, are not effective against multidrug-resistant (MDR) fungal strains, and are associated with substantial toxicity in clinical use. This Microperspective summarizes challenges pertaining to antifungal drug discovery in addition to highlighting recent advances and antifungal agents in clinical trials.

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Conflict of interest statement

The authors declare no competing financial interest.

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References

    1. Bongomin F.; Gago S.; Oladele R. O.; Denning D. W. Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision. J. Fungi 2017, 3, 57.10.3390/jof3040057. - DOI - PMC - PubMed
    1. Denning D. W. Global incidence and mortality of severe fungal disease. Lancet Infect. Dis. 2024, 24, e428–38. 10.1016/S1473-3099(23)00692-8. - DOI - PubMed
    1. Gow N. A. R.; Johnson C.; Berman J.; Coste A. T.; Cuomo C. A.; Perlin D. S.; Bicanic T.; Harrison T. S.; Wiederhold N.; Bromley M.; Chiller T.; Edgar K. The importance of antimicrobial resistance in medical mycology. Nat. Commun. 2022, 13, 5352.10.1038/s41467-022-32249-5. - DOI - PMC - PubMed
    1. Kusakabe T.; Lin W. Y.; Cheong J. G.; et al. Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19. Nat. Immunol. 2023, 24, 1879.10.1038/s41590-023-01637-4. - DOI - PMC - PubMed
    1. Santos E.; Levitz S. M. Fungal Vaccines and Immunotherapeutics. Cold Spring Harb. Perspect. Med. 2014, 4, a019711.10.1101/cshperspect.a019711. - DOI - PMC - PubMed

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