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Review
. 2025 Mar 4:12:1539578.
doi: 10.3389/fnut.2025.1539578. eCollection 2025.

Diet, oxidative stress and MAFLD: a mini review

Zenan Hu #  1   2 , Hanxun Yue #  2 , Na Jiang  3 , Liang Qiao  4
Affiliations
Review

Diet, oxidative stress and MAFLD: a mini review

Zenan Hu et al. Front Nutr. .

Abstract

Globally, metabolic dysfunction-associated fatty liver disease (MAFLD), also known as non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), is a common chronic liver disease. The progression of MAFLD leads to a vicious cycle in which oxidative stress results from the disease that is augmenting de-novo lipid levels and increases steatosis. Most non-enzymatic antioxidants are present in food. Therefore, the present review summarizes the findings of studies on food-derived antioxidants and presents an oxidative stress-related regulatory network in MAFLD, offering new ideas for MAFLD prevention and treatment.

Keywords: MAFLD; MASLD; NAFLD; diet; oxidative stress.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Regulatory network of food-derived antioxidants in oxidative stress in hepatocytes.
See this image and copyright information in PMC

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