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. 2025 Aug;51(2):510-517.
doi: 10.1111/aej.12936. Epub 2025 Mar 19.

Genetic Polymorphisms and Their Association With Endodontic Postoperative Pain: A Systematic Review

Ertuğrul Karataş  1 , Çiğdem Yüce Kahraman  2 , Hussna Khan  3 , Zehra Yonel  4
Affiliations

Genetic Polymorphisms and Their Association With Endodontic Postoperative Pain: A Systematic Review

Ertuğrul Karataş et al. Aust Endod J. 2025 Aug.

Abstract

The present systematic review aims to investigate whether currently available evidence supports a possible association between Single Nucleotide Polymorphism (SNP) and the level of Endodontic Postoperative Pain (EPP). Studies including human participants and those evaluating the association between SNPs and EPP were included. A total of 618 articles were identified following the initial search of electronic databases. Of these, 50 were found in Scopus, 13 in PubMed, 26 in Web of Science, and 529 in Google Scholar databases. Out of the 4 included studies, 3 reported a significant association between the selected SNPs and EPP. The present systematic review suggests that there is a possible association between genetic polymorphisms and the level of pain following root canal treatment. However, it is impossible to conclude that a specific SNP is associated with EPP based on the included studies investigating different genes and SNPs with a small sample size.

Keywords: endodontic postoperative pain; genetic variants; single nucleotide polymorphism.

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References

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