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. 2025 Mar;66 Suppl 1(Suppl 1):1-3.
doi: 10.1111/epi.18306.

Do the third-generation antiseizure medications provide the "magic bullet" for drug-resistant epilepsy? Focus on cenobamate

Patrick Kwan  1 , Martin J Brodie  2
Affiliations

Do the third-generation antiseizure medications provide the "magic bullet" for drug-resistant epilepsy? Focus on cenobamate

Patrick Kwan et al. Epilepsia. 2025 Mar.
No abstract available

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Conflict of interest statement

Dr. Kwan is supported by the National Health and Medical Research Council (NHMRC) Investigator Grants (GNT2025849). Outside the submitted work he/his institution has received consultancy fees and/or research grants from Eisai, Jazz, LivaNova, SK Life Science, Inc., and UCB Pharma. Dr. Brodie has nothing to disclose.

We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

References

    1. Löscher W, Klein P. The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond. CNS Drugs. 2021;35(9):935–963. 10.1007/s40263-021-00827-8 - DOI - PMC - PubMed
    1. Perucca E, Brodie MJ, Kwan P, Tomson T. 30 years of second‐generation antiseizure medications: impact and future perspectives. Lancet Neurol. 2020;19(6):544–556. 10.1016/s1474-4422(20)30035-1 - DOI - PubMed
    1. Chen Z, Brodie MJ, Liew D, Kwan P. Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30‐year longitudinal cohort study. JAMA Neurol. 2018;75(3):279–286. 10.1001/jamaneurol.2017.3949 - DOI - PMC - PubMed
    1. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342(5):314–319. 10.1056/nejm200002033420503 - DOI - PubMed
    1. Janmohamed M, Hakeem H, Ooi S, Hakami S, Vu L, Perucca P, et al. Treatment outcomes of newly diagnosed epilepsy: a systematic review and meta‐analysis. CNS Drugs. 2023;37(1):13–30. 10.1007/s40263-022-00979-1 - DOI - PubMed

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