Exploring the anti-anaphylaxis potential of natural products: A Review

Abstract

Allergies are a common health issue affecting many people around the world, especially in developed countries. They occur when the immune system overreacts to substances that are usually harmless. Some common allergic conditions include asthma, sinus infections, skin rashes, food allergies, hay fever, severe allergic reactions, eczema, swelling, and reactions to medications or insect stings. The causes of these allergies are complex and often linked to genetics, which can lead to heightened immune responses known as atopy. Throughout history, plant extracts have been used for various purposes, including medicine and food. In addition, their bioactive compounds show a wide range of beneficial effects, such as reducing allergic reactions, fighting oxidative stress, mast cell stabilizers, and lowering inflammation, highlighting their potential for treating various health conditions. Flavonoids and phenolic compounds are commonly used in anaphylaxis for their potent anti-inflammatory action. This review aims to promote the use of natural products as potential treatments for anaphylaxis. In addition, the discovery of new drugs derived from natural sources holds significant promise for the management of anaphylaxis.

Keywords: Allergy; Anaphylaxis; Inflammatory mediators; Mast cells; Natural products.

Fig. 1

IgE-mediated anaphylaxis

Fig. 2

Systematic representation for preliminary management of anaphylaxis

Fig. 3

Anaphylaxis immunomodulatory–inflammatory multi-axis via sensitization and effector phases

Fig. 4

Relation between oxidative stress and mast cell degranulation

Fig. 5

Polyphenols defeat oxidative stress action towards mast cell degranulation

Fig. 6

Summary of the polyphenols most common anti-anaphylactic effect among anaphylaxis pathways