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. 2025:2960:85-93.
doi: 10.1007/7651_2025_609.

Evaluation of Anti-aging Agents Using the D-Galactose-Induced Accelerated Aging Model

Serdar Bora Bayraktaroğlu  1   2 , Raife Dilek Turan  1 , Neslihan Pakize Taşlı  1 , Fikrettin Şahin  1
Affiliations

Evaluation of Anti-aging Agents Using the D-Galactose-Induced Accelerated Aging Model

Serdar Bora Bayraktaroğlu et al. Methods Mol Biol. 2025.

Abstract

The aging population is rapidly increasing, emphasizing the importance of understanding aging mechanisms and developing effective anti-aging therapies. This chapter investigates the efficacy of novel anti-aging agents, including exosomes and boron compounds, using the D-galactose-induced accelerated aging model. Both in vitro (skin organoid models) and in vivo (rat models) systems are employed to explore cellular, molecular, and histological changes. This comprehensive analysis provides critical insights into the potential of these agents in reversing age-associated pathologies.

Keywords: Accelerated model; Aging aging; Anti-aging applications; D-Galactose; Reactive oxygen species.

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