Clonal Hematopoiesis of Indeterminate Potential and Incident Hypertension: Results From the Women's Health Initiative

Bernhard Haring^{1

2}, Aaron K Aragaki^{3

4}, Daichi Shimbo⁵, Stephen R Rapp⁶, Charles B Eaton⁷, Michael J LaMonte⁸, Jean Wactawski-Wende⁸, Matthew A Allison⁹, Aladdin H Shadyab¹⁰, Jacques E Rossouw⁴, Eric A Whitsel¹¹, Nora Franceschini¹¹, Charles Kooperberg³, Pinkal Desai¹², Michael S Simon¹³, Michael Böhm¹, Pradeep Natarajan¹⁴, Sylvia Wassertheil-Smoller², JoAnn E Manson¹⁵

Affiliations

¹ Department of Medicine III, Saarland University, Homburg, Germany (B.H., M.B.).
² Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (B.H., S.W.-S.).
³ Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle, WA (A.K.A., C.K.).
⁴ Women's Health Initiative, Seattle, WA (A.K.A., J.E.R.).
⁵ Department of Cardiology, Columbia University Irving Medical Center, New York, NY (D.S.).
⁶ Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC (S.R.R.).
⁷ Department of Family Medicine, Warren Alpert Medical School, and the Department of Epidemiology, School of Public Health, Brown University, Providence, RI (C.B.E.).
⁸ Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo - SUNY, NY (M.J.L.M., J.W.-W.).
⁹ Department of Family Medicine, University of California, San Diego, La Jolla (M.A.A.).
¹⁰ Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla (A.H.S.).
¹¹ Department of Epidemiology, Gillings School of Global Public Health University of North Carolina, Chapel Hill (N.F., E.A.W.).
¹² Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY (P.D.).
¹³ Department of Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, MI (M.S.S.).
¹⁴ Department of Medicine, Harvard Medical School, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (P.N.).
¹⁵ Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School and Harvard T.H. Chan School of Public Health, Boston, MA (J.A.E.M.).

PMID: 40106531
PMCID: PMC11925488 (available on 2026-04-01)
DOI: 10.1161/HYPERTENSIONAHA.124.24482

Clonal Hematopoiesis of Indeterminate Potential and Incident Hypertension: Results From the Women's Health Initiative

Bernhard Haring et al. Hypertension. 2025 Apr.

. 2025 Apr;82(4):e70-e72.

doi: 10.1161/HYPERTENSIONAHA.124.24482. Epub 2025 Mar 19.

Authors

Affiliations

¹ Department of Medicine III, Saarland University, Homburg, Germany (B.H., M.B.).
² Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (B.H., S.W.-S.).
³ Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle, WA (A.K.A., C.K.).
⁴ Women's Health Initiative, Seattle, WA (A.K.A., J.E.R.).
⁵ Department of Cardiology, Columbia University Irving Medical Center, New York, NY (D.S.).
⁶ Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC (S.R.R.).
⁷ Department of Family Medicine, Warren Alpert Medical School, and the Department of Epidemiology, School of Public Health, Brown University, Providence, RI (C.B.E.).
⁸ Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo - SUNY, NY (M.J.L.M., J.W.-W.).
⁹ Department of Family Medicine, University of California, San Diego, La Jolla (M.A.A.).
¹⁰ Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla (A.H.S.).
¹¹ Department of Epidemiology, Gillings School of Global Public Health University of North Carolina, Chapel Hill (N.F., E.A.W.).
¹² Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY (P.D.).
¹³ Department of Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, MI (M.S.S.).
¹⁴ Department of Medicine, Harvard Medical School, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (P.N.).
¹⁵ Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School and Harvard T.H. Chan School of Public Health, Boston, MA (J.A.E.M.).

PMID: 40106531
PMCID: PMC11925488 (available on 2026-04-01)
DOI: 10.1161/HYPERTENSIONAHA.124.24482

No abstract available

Keywords: blood pressure; clonal hematopoiesis/genetics; hypertension.

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Conflict of interest statement

B. Haring reports speaker honoraria from Pfizer and Bristol-Myers Squibb. M. Böhm is supported by the German Research Foundation and reports personal fees from Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Cytokinetics, Medtronic, Novartis, ReCor, Servier, and Vifor. P. Natarajan reports research grants from Allelica, Apple, Amgen, Boston Scientific, Genentech/Roche, and Novartis; personal fees from Allelica, Apple, AstraZeneca, Blackstone Life Sciences, Foresite Labs, Genentech/Roche, GV, HeartFlow, Magnet Biomedicine, and Novartis; scientific advisory board membership of Esperion Therapeutics, Preciseli, and TenSixteen Bio; scientific cofounder of TenSixteen Bio, equity in Preciseli and TenSixteen Bio, and spousal employment at Vertex Pharmaceuticals, all unrelated to the present work. The other authors report no conflicts.

References

1. Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, et al. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020;586:763–768. doi: 10.1038/s41586-020-2819-2 - DOI - PMC - PubMed
1. Breslow NE, Amorim G, Pettinger MB, Rossouw J. Using the Whole Cohort in the Analysis of Case-Control Data: Application to the Women’s Health Initiative. Stat Biosci. 2013;5. doi: 10.1007/s12561-013-9080-2 - DOI - PMC - PubMed
1. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371:2488–2498. doi: 10.1056/NEJMoa1408617 - DOI - PMC - PubMed
1. Polizio AH, Marino L, Min KD, Yura Y, Rolauer L, Cochran JD, Evans MA, Park E, Doviak H, Miura-Yura E, et al. Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism. Circ Res. 2024;135:933–950. doi: 10.1161/circresaha.124.324492 - DOI - PMC - PubMed
1. Kessler MD, Damask A, O’Keeffe S, Banerjee N, Li D, Watanabe K, Marketta A, Van Meter M, Semrau S, Horowitz J, et al. Common and rare variant associations with clonal haematopoiesis phenotypes. Nature. 2022;612:301–309. doi: 10.1038/s41586-022-05448-9 - DOI - PMC - PubMed

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Clonal Hematopoiesis of Indeterminate Potential and Incident Hypertension: Results From the Women's Health Initiative

Affiliations

Clonal Hematopoiesis of Indeterminate Potential and Incident Hypertension: Results From the Women's Health Initiative

Authors

Affiliations

Conflict of interest statement

References

Publication types

Grants and funding

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