[Effect of bacterial lipopolysaccharide (S. minnesota R 595) on the luminol-dependent chemiluminescence of neutrophilic granulocytes in cord blood]

Abstract

The effect of bacterial lipopolysaccharide (S. minnesota R 595) (LPS) on the luminol dependent chemiluminescence (LUM-CL) of resting and phagocytosing polymorphonuclear leukocytes (PMN) in cord blood or healthy adults has been investigated. The inhibitory effect of LPS on the LUM-CL of phagocytosing cord blood PMN has been much more pronounced than on the LUM-CL of adult PMN. The emission curves showed a delayed reaction in cord blood PMN and in contrast to this finding an accelerated reaction in adult PMN. LPS stimulated the photone emission of resting PMN of both groups in comparable intensity.