Unveiling GULP1 as a hepatocyte-specific role for recurrence: Editorial on "GULP1 as a novel diagnostic and predictive biomarker in hepatocellular carcinoma"

Affiliations

Editorial

Pengde Lu et al. Clin Mol Hepatol. 2026 Jan.

. 2026 Jan;32(1):410-412.

doi: 10.3350/cmh.2025.0282. Epub 2025 Mar 19.

¹ School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R., P.R. China.

No abstract available

Keywords: Biomarker; GULP1; Hepatocellular carcinoma; Prediction; Recurrence.

Conflict of interest statement

Conflicts of Interest

The authors declare no conflicts of interest.

Correspondence to editorial on "GULP1 as a novel diagnostic and predictive biomarker in hepatocellular carcinoma".
Kim SS, Kim HS, Cheong JY, Eun JW. Kim SS, et al. Clin Mol Hepatol. 2026 Jan;32(1):e72-e74. doi: 10.3350/cmh.2025.0350. Epub 2025 Apr 4. Clin Mol Hepatol. 2026. PMID: 40181674 Free PMC article. No abstract available.

GULP1 as a novel diagnostic and predictive biomarker in hepatocellular carcinoma.
Kim HS, Yoon JH, Choi JY, Yoon MG, Baek GO, Kang M, Jang SH, Park W, Go Y, Ng JT, Nam SW, Jeong JY, Han JE, Cho HJ, Lim SB, Kim SS, Cheong JY, Eun JW. Kim HS, et al. Clin Mol Hepatol. 2025 Jul;31(3):914-934. doi: 10.3350/cmh.2024.1038. Epub 2025 Feb 6. Clin Mol Hepatol. 2025. PMID: 39914372 Free PMC article.

1. Llovet JM, Pinyol R, Yarchoan M, Singal AG, Marron TU, Schwartz M, et al. Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma. Nat Rev Clin Oncol. 2024;21:294–311. - PMC - PubMed
1. Norman JS, Li PJ, Kotwani P, Shui AM, Yao F, Mehta N. AFPL3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation. J Hepatol. 2023;79:1469–1477. - PMC - PubMed
1. Chau DD, Yung KW, Chan WW, An Y, Hao Y, Chan HE, et al. Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35. FASEB J. 2019;33:12019–12035. - PMC - PubMed
1. Chau DD, Yu Z, Chan WWR, Yuqi Z, Chang RCC, Ngo JCK, et al. The cellular adaptor GULP1 interacts with ATG14 to potentiate autophagy and APP processing. Cell Mol Life Sci. 2024;81:323. - PMC - PubMed
1. Tatenuma T, Matsukawa T, Goto T, Jiang G, Sharma A, Najafi MAE, et al. GULP1 as a downstream effector of the estrogen receptor-β modulates cisplatin sensitivity in bladder cancer. cancer genomics proteomics. 2024;21:557–565. - PMC - PubMed