Recent advances in DNA nanotechnology for cancer detection and therapy: A review

Abstract

Deoxyribonucleic acid (DNA) nanotechnology has rapidly emerged as a transformative field in biomedical research, offering innovative solutions for the detection and treatment of cancer. This review provides a comprehensive analysis of the role of DNA-based nanosystems in oncology, emphasizing their potential to address the limitations of conventional diagnostic and therapeutic approaches. Key advancements in DNA nanotechnology include the development of highly specific and sensitive nanostructures for early cancer detection, as well as precision-targeted delivery systems that enhance the efficacy of cancer therapies while minimizing side effects. The objectives of this review are threefold: first, to summarize the latest advancements in DNA nanotechnology, highlighting innovations in cancer biomarker detection and therapeutic applications; second, to explore the molecular mechanisms that enable these DNA-based nanosystems to interact with cancer cells with remarkable precision, including their design principles, self-assembly processes, and biological interactions; and third, to discuss the future implications of these technologies, considering the challenges, potential breakthroughs, and the steps needed to integrate DNA nanotechnology into clinical practice. By achieving these objectives, the review aims to offer insights into how DNA nanotechnology could revolutionize cancer care, providing new strategies for more personalized and effective treatments, and ultimately improving patient outcomes in the battle against cancer.

Keywords: Cancer detection; DNA nanotechnology; DNA origami; Nanomedicine; Precision medicine.