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Review
. 2025 Jun:233:162-173.
doi: 10.1016/j.freeradbiomed.2025.03.025. Epub 2025 Mar 17.

The two faces of coenzyme A in cellular biology

Charlie Brett  1 , Ivan Gout  2
Affiliations
Review

The two faces of coenzyme A in cellular biology

Charlie Brett et al. Free Radic Biol Med. 2025 Jun.

Abstract

Coenzyme A (CoA) is an essential cofactor present in all living cells, which plays critical roles in diverse biochemical processes, including cellular metabolism, signal transduction, regulation of gene expression, and the antioxidant response. This review summarizes current knowledge on the role of CoA and its metabolically active thioesters in promoting cellular growth and proliferation (pro-growth) and discusses emerging research on CoA's antioxidant properties that enhance cell survival (pro-survival).

Keywords: Antioxidant function; Cellular metabolism; Coenzyme A; Protein CoAlation; Signal transduction.

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Conflict of interest statement

Declaration of competing interest The authors do not have a conflict of interest to report.

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