Coronary Artery Disease and Heart Failure: Medical Management and Future Direction

Abstract

Coronary artery disease (CAD) is a leading etiology of heart failure (HF) and serves as a significant therapeutic target to ameliorate HF-associated morbidity and mortality. Key management considerations include pharmacologic treatment, electrophysiological devices, and coronary revascularization, aimed toward preventing CAD progression, left ventricular remodeling, sudden death, and reinfarction. The optimal revascularization strategy for patients with CAD and HF who are surgical candidates requires careful assessment of each patients' unique risk/benefit profile and individual preferences. Several novel pharmacologic agents are in development with hopes of adding to the armamentarium of treatment of CAD and HF.

Keywords: Coronary artery bypass grafting; Coronary artery disease; Heart failure; Ischemic cardiomyopathy; Myocardial infarction; Percutaneous coronary intervention.