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. 2025 Mar 5:13:1558256.
doi: 10.3389/fped.2025.1558256. eCollection 2025.

Characteristics of children with severe preschool asthma prior to starting the TIPP study

S Zielen  1 , J Wosniok  2 , N Wollscheid  2 , T Nickolay  2 , C Grimmel  3 , D Scheele  1 , F Sattler  4 , F Prenzel  5 , M Lorenz  6 , B Schaub  4 , C Lex  7 , M Dahlheim  8 , J Trischler  1 , H Donath  1 , S Lau  9 , E Hamelmann  10   11 , C Vogelberg  11 , M Gerstlauer  12 , M Wetzke  13 , R Schubert  1 , L Schollenberger  2 , M Gappa  3
Affiliations

Characteristics of children with severe preschool asthma prior to starting the TIPP study

S Zielen et al. Front Pediatr. .

Abstract

Objective: Children with preschool asthma suffer disproportionally more often from severe asthma exacerbations with emergency visits and hospital admissions than school children. However, there are only a few reports on characteristics, hospitalization, phenotypes and symptoms in this age cohort.

Patients and methods: This analysis of an ongoing prospective trial of Tiotropium bromide in preventing severe asthma exacerbations (the TIPP study) assessed baseline characteristics, hospitalizations and symptoms in 100 children with severe preschool asthma. Children aged 1-5 years were analyzed at study enrollment and daily symptoms were recorded by an electronic diary [Pediatric Asthma Caregiver Diary (PACD)] for the following four weeks until randomization.

Results: At enrollment, the total number of severe asthma exacerbations, defined as three days systemic steroid use or hospitalization in the last 24 months, was mean (±SD) 5.8 ± 5.7 and the test for respiratory and asthma control in kids (TRACK) was mean 46.9 ± 19.0. Daily recording of symptoms by the PACD revealed that only 7 patients were controlled at randomization, whereas 35 were partially and 58 were uncontrolled according to GINA.

Conclusion: Despite protective therapy with inhaled corticosteroids (ICS), most children of this severe asthma cohort were only partially or uncontrolled according to GINA guidelines.

Keywords: PACD; asthma phenotypes; hospitalization; preschool asthma; tiotropium bromide; uncontrolled asthma.

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Conflict of interest statement

SZ reports grants and personal fees from Engelhard-Arzneimittel GmbH, personal fees from Stallergen, AstraZeneca, Sanofi/Pasteur, Erydel, and Allergy therapeutics outside the submitted work. The remaining authors declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of study patients.
See this image and copyright information in PMC

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