LogODDS as a prognostic factor in oral cavity squamous cell carcinoma

Abstract

The objective of the study is to estimate the role of LogODDS as a prognostic factor in patients affected by oral cavity squamous cell carcinoma, in terms of overall survival (OS) and disease-free survival (DFS), looking for a cut-off value that allows to stratify them in high and low risk of recurrency, implementing the informations given by Lymph Node Ratio (LNR) and TNM 8th. Seventyfour patients affected by oral cavity squamous cell carcinoma with metastatic lymph nodes who have undergone surgery at Maxillofacial Surgery Unit of the Fondazione IRCCS Cà Granda Ospedale Policlinico di Milano, in which a restaging according to TNM 8th was possible and LNR and LogODDS could have been calculated, were enrolled. Multivariate analysis for OS was statistically relevant for both LogODDS and LNR, where N alone didn't reach the same result. No one of the previous parameters has a statistically relevant meaning in DFS prediction. LogODDS as a prognostic factor has a statistically compelling meaning in order to predict overall survival in oral squamous cell carcinoma.

Keywords: LogODDS; Lymph node ratio; Oral cancer; Oral squamous cell carcinoma; Prognostic factors.