doi: 10.1017/s0031182000052306.
How anthelmintics help us to understand helminths
- PMID: 4011323
- DOI: 10.1017/s0031182000052306
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How anthelmintics help us to understand helminths
Parasitology.
1985 Apr.
Abstract
Study of the mode of action of the anti-parasitic 'hydrogenophore', closantel, revealed that mitochondria isolated from livers of untreated rats, 13 weeks after infection with Fasciola hepatica metacercariae, were uncoupled. This uncoupling of mitochondria might be induced by a product(s) excreted by the liver fluke. The lipid extractable product(s) binds to albumin and has a molecular weight between 500 and 1000 Daltons. A second unexpected finding indicates that closantel affects the motility of Schistosoma mansoni in vitro by interfering with mitochondrial ATP synthesis. The results obtained are suggestive of a role for aerobic metabolism in the generation of energy required for motility.
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