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. 2025 Apr 3;65(4):2402427.
doi: 10.1183/13993003.02427-2024. Print 2025 Apr.

Accelerated biological ageing in familial pulmonary fibrosis

Ana P M Serezani  1 , Daphne B Mitchell  2 , Joy D Cogan  2 , M Merced U Malabanan  3 , Cheryl R Markin  3 , Errine T Garnett  3 , Tisra H Fadely  3 , Jonathan A Kropski  3   4   5 , Margaret L Salisbury  3 , Timothy S Blackwell  3   4   5   6
Affiliations

Accelerated biological ageing in familial pulmonary fibrosis

Ana P M Serezani et al. Eur Respir J. .
No abstract available

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Conflict of interest statement

Conflict of interest: A.P.M. Serezani received funding from the National Institutes of Health (NIH). T.S. Blackwell received funding from NIH, Boehringer Ingelheim, the US Department of Veterans Affairs and Bristol Meyers Squibb. M.L. Salisbury received funding from NIH and Boehringer Ingelheim, and personal fees for consulting for Orinove, Inc. J.A. Kropski received funding from NIH, Boehringer Ingelheim and the Three Lakes Foundation. The remaining authors declare no major competing interests related to this study.

Figures

Figure 1.
Figure 1.. Epigenetic analysis of subjects with familial pulmonary fibrosis (FPF) and at-risk relatives indicates accelerated biological ageing.
a) Schematic representation of epigenetic age and features of biological ageing in FPF. b) Characteristics of participants selected for DNA-associated ageing analysis. Data are presented as mean±sd. c) ΔDNAge (difference between epigenetic age and chronological age) determined from DNA isolated from whole blood of healthy controls, at-risk subjects in FPF kindreds, and FPF patients. ΔDNAge of d) at-risk and e) FPF probands with mean telomere terminal restriction fragment length (MTL) as indicated (% adjusted for age based on MTL values observed in normal control subjects). f) ΔDNAge of at-risk and FPF probands with and without pathogenic rare variants (RVs) in telomere maintenance genes. Box and whisker plots represent median values and interquartile ranges. *: p<0.05; **: p<0.0001.
See this image and copyright information in PMC

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