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Review
. 2025 Mar;39(1S):e1-e31.
doi: 10.1016/j.idc.2025.01.001. Epub 2025 Mar 19.

Current Antifungals and the Developing Pipeline

Melissa D Johnson  1 , W Justin Moore  2
Affiliations
Review

Current Antifungals and the Developing Pipeline

Melissa D Johnson et al. Infect Dis Clin North Am. 2025 Mar.

Abstract

Prevention and management of invasive fungal infections is challenging due to the complexity of at-risk patient population, high morbidity and mortality of these infections, and pharmacologic aspects of available antifungal agents. While there has been substantial investment in antifungal drug development over past 20 years, the ideal antifungal remains elusive. Clinicians must be aware of differences in spectrum of activity, pharmacokinetic/dynamic dosing, toxicity, resistance, and drug interaction profiles of antifungals to use them most effectively. This article will review key features of U.S. Food and Drug Administration-approved and pipeline antifungals to facilitate an understanding of their role in treatment and/or prevention of invasive fungal infections.

Keywords: Antifungal drugs; Azoles; Echinocandins; Invasive fungal infections; Novel therapies; Pipeline; Polyenes; Review.

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Conflict of interest statement

Disclosure Dr M.D. Johnson has the following to disclose: Patent Pending PCT/US2022/015,195 for gene expression-based classifiers of fungal infection (Methods to Detect and Treat a Fungal Infection) with technology licensed to Biomene (Transcriptional Signature for Candidemia), research grants to her institution from Scynexis and Charles River Laboratories, Inc, United States, and author royalties from UpToDate.

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