Will "Sun"-WUKONG, the monkey king, conquer EGFR exon 20 insertion mutation positive non-small cell lung cancer?
- PMID: 40114957
- PMCID: PMC11921394
- DOI: 10.21037/tlcr-24-854
Will "Sun"-WUKONG, the monkey king, conquer EGFR exon 20 insertion mutation positive non-small cell lung cancer?
Keywords: EGFR exon 20 insertion mutations; EGFR tyrosine kinase inhibitors; sunvozertinib; uncommon EGFR mutations.
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-24-854/coif). M.L. reports research funding from AstraZeneca, Gilead, MSD, Takeda, and Johnson & Johnson; honoraria from AstraZeneca, Novartis, Amgen, Pfizer, Takeda, ACE Oncology, Gilead, Guardant Health, Johnson & Johnson, Merck, MSD and BMS; support for attending meetings from AstraZeneca, Pfizer, Daiichi Sankyo, MSD, Roche, Johnson & Johnson, and Amgen; and has participation on advisory board of AstraZeneca, Pfizer, Takeda, Amgen, AnHeart Therapeutics, Yuhan, Blossomhill Therapeutics, and Johnson & Johnson. R.A.S. reports receiving research funding from AstraZeneca, Boehringer Ingelheim, Pfizer; honoraria for lectures, presentations from Abbvie, Amgen, AnHeart, Astra-Zeneca, Bayer, BMS, Boehringer Ingelheim, Chugai, Daiichi Sankyo, GSK, J INTS BIO, Janssen, Lily, Merck, Merck Serono, Novartis, Pfizer, Puma, Roche, Sanofi, Taiho, Takeda, Thermo Fisher, Yuhan Corporation and has participation on Advisory Board of Abbvie, Amgen, AnHeart, Astra-Zeneca, Bayer, BMS, Boehringer Ingelheim, Daiichi Sankyo, GSK, J INTS BIO, Janssen, Lily, Merck, Merck Serono, Novartis, Pfizer, Puma, Roche, Sanofi, Taiho, Takeda, Thermo Fisher, Yuhan Corporation. The authors have no other conflicts of interest to declare.
Comment on
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Sunvozertinib for patients in China with platinum-pretreated locally advanced or metastatic non-small-cell lung cancer and EGFR exon 20 insertion mutation (WU-KONG6): single-arm, open-label, multicentre, phase 2 trial.Lancet Respir Med. 2024 Mar;12(3):217-224. doi: 10.1016/S2213-2600(23)00379-X. Epub 2023 Dec 12. Lancet Respir Med. 2024. PMID: 38101437 Clinical Trial.
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