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Editorial
. 2025 Feb 28;14(2):263-267.
doi: 10.21037/gs-24-472. Epub 2025 Feb 25.

Stepped-wedge clinical trials in pancreatic cancer: a step backward in improving overall survival or a leap forward to enhance quality of care?

Mauro Daniel Spina Donadio  1 , Victor Hugo Fonseca de Jesus  2   3
Affiliations
Editorial

Stepped-wedge clinical trials in pancreatic cancer: a step backward in improving overall survival or a leap forward to enhance quality of care?

Mauro Daniel Spina Donadio et al. Gland Surg. .
No abstract available

Keywords: Stepped-wedge; cancer; intervention; pancreatic; policy.

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://gs.amegroups.com/article/view/10.21037/gs-24-472/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Schematic representation of cluster randomized trials [adapted from reference (10)]. Stepped-wedge cluster design (A), parallel cluster design (B), and stepped-wedge cluster design with a transition period (C).
See this image and copyright information in PMC

Comment on

  • Implementation of Best Practices in Pancreatic Cancer Care in the Netherlands: A Stepped-Wedge Randomized Clinical Trial.
    Mackay TM, Latenstein AEJ, Augustinus S, van der Geest LG, Bogte A, Bonsing BA, Cirkel GA, Hol L, Busch OR, den Dulk M, van Driel LMJW, Festen S, de Groot DA, de Groot JB, Groot Koerkamp B, Haj Mohammad N, Haver JT, van der Harst E, de Hingh IH, Homs MYV, Los M, Luelmo SAC, de Meijer VE, Mekenkamp L, Molenaar IQ, Patijn GA, Quispel R, Römkens TEH, van Santvoort HC, Stommel MWJ, Venneman NG, Verdonk RC, van Vilsteren FGI, de Vos-Geelen J, van Werkhoven CH, van Hooft JE, van Eijck CHJ, Wilmink JW, van Laarhoven HWM, Besselink MG; Dutch Pancreatic Cancer Group. Mackay TM, et al. JAMA Surg. 2024 Apr 1;159(4):429-437. doi: 10.1001/jamasurg.2023.7872. JAMA Surg. 2024. PMID: 38353966 Free PMC article. Clinical Trial.

References

    1. Rahib L, Wehner MR, Matrisian LM, et al. Estimated Projection of US Cancer Incidence and Death to 2040. JAMA Netw Open 2021;4:e214708. 10.1001/jamanetworkopen.2021.4708 - DOI - PMC - PubMed
    1. de Jesus VHF, Riechelmann RP. Current Treatment of Potentially Resectable Pancreatic Ductal Adenocarcinoma: A Medical Oncologist's Perspective. Cancer Control 2023;30:10732748231173212. 10.1177/10732748231173212 - DOI - PMC - PubMed
    1. Mastrantoni L, Chiaravalli M, Spring A, et al. Comparison of first-line chemotherapy regimens in unresectable locally advanced or metastatic pancreatic cancer: a systematic review and Bayesian network meta-analysis. Lancet Oncol 2024;25:1655-65. 10.1016/S1470-2045(24)00511-4 - DOI - PubMed
    1. Sarkar RR, Matsuno R, Murphy JD. Pancreatic cancer: Survival in clinical trials versus the real world. J Clin Oncol 2016;34:216.
    1. de Jesus VHF, da Costa WL, Jr, Claro LCL, et al. Disparities in access to health care system as determinant of survival for patients with pancreatic cancer in the State of São Paulo, Brazil. Sci Rep 2021;11:6346. 10.1038/s41598-021-85759-5 - DOI - PMC - PubMed

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